| 5. Round | 19/09/2010 | Karlsruher SC [Youth] | - | 1899 Hoffenheim [Youth] | 1:2 | ||||
| 6. Round | 03/10/2010 | 1899 Hoffenheim [Youth] | - | 1. FSV Mainz 05 [Youth] | 1:4 |  |
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| 7. Round | 17/10/2010 | Bayern München [Youth] | - | 1899 Hoffenheim [Youth] | 2:1 | |
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| 8. Round | 24/10/2010 | 1899 Hoffenheim [Youth] | - | Eintracht Frankfurt [Youth] | 1:1 | |
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| 16. Round | 26/02/2011 | 1899 Hoffenheim [Youth] | - | 1. FC Nürnberg [Youth] | 3:1 | ||||
| 17. Round | 05/03/2011 | SpVgg Greuther Fürth [Youth] | - | 1899 Hoffenheim [Youth] | 6:1 | ||||
| 18. Round | 13/03/2011 | 1899 Hoffenheim [Youth] | - | Karlsruher SC [Youth] | 2:0 | ||||
| 19. Round | 19/03/2011 | 1. FSV Mainz 05 [Youth] | - | 1899 Hoffenheim [Youth] | 2:2 | ||||
| 20. Round | 03/04/2011 | 1899 Hoffenheim [Youth] | - | Bayern München [Youth] | 2:2 | |
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| 21. Round | 10/04/2011 | Eintracht Frankfurt [Youth] | - | 1899 Hoffenheim [Youth] | 2:0 | ||||
| 22. Round | 16/04/2011 | VfB Stuttgart [Youth] | - | 1899 Hoffenheim [Youth] | 1:1 |
Germany