| 1. Round | 07/08/2005 | Hansa Rostock | - | Kickers Offenbach | 1:2 | ||||
| 2. Round | 14/08/2005 | Kickers Offenbach | - | SpVgg Greuther Fürth | 2:1 |  |
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| 3. Round | 26/08/2005 | Dynamo Dresden | - | Kickers Offenbach | 4:1 | ||||
| 4. Round | 11/09/2005 | Kickers Offenbach | - | SC Freiburg | 2:1 | ||||
| 5. Round | 16/09/2005 | Kickers Offenbach | - | TSV 1860 München | 2:5 | |
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| 6. Round | 20/09/2005 | Eintracht Braunschweig | - | Kickers Offenbach | 2:0 | ||||
| 7. Round | 23/09/2005 | Kickers Offenbach | - | VfL Bochum | 0:0 | ||||
| 8. Round | 02/10/2005 | SC Paderborn 07 | - | Kickers Offenbach | 4:1 | ||||
| 18. Round | 22/01/2006 | Kickers Offenbach | - | Hansa Rostock | 1:3 | ||||
| 19. Round | 29/01/2006 | SpVgg Greuther Fürth | - | Kickers Offenbach | 2:0 | ||||
| 26. Round | 17/03/2006 | Sportfreunde Siegen | - | Kickers Offenbach | 1:1 | ||||
| 33. Round | 07/05/2006 | Kickers Offenbach | - | Energie Cottbus | 2:0 |
Germany