| 1. Round | 10/08/2007 | VfB Stuttgart | - | FC Schalke 04 | 2:2 | ||||
| 2. Round | 18/08/2007 | FC Schalke 04 | - | Borussia Dortmund | 4:1 |  |
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| 3. Round | 26/08/2007 | VfL Wolfsburg | - | FC Schalke 04 | 1:1 | ||||
| 4. Round | 31/08/2007 | FC Schalke 04 | - | Bayer Leverkusen | 1:1 | ||||
| 5. Round | 15/09/2007 | Bayern München | - | FC Schalke 04 | 1:1 | ||||
| 6. Round | 22/09/2007 | FC Schalke 04 | - | Arminia Bielefeld | 3:0 | ||||
| 7. Round | 25/09/2007 | MSV Duisburg | - | FC Schalke 04 | 0:2 | ||||
| 8. Round | 28/09/2007 | FC Schalke 04 | - | Hertha BSC | 1:0 | ||||
| 11. Round | 27/10/2007 | FC Schalke 04 | - | Werder Bremen | 1:1 | ||||
| 23. Round | 08/03/2008 | Arminia Bielefeld | - | FC Schalke 04 | 0:2 | ||||
| 24. Round | 14/03/2008 | FC Schalke 04 | - | MSV Duisburg | 2:1 | ||||
| 25. Round | 23/03/2008 | Hertha BSC | - | FC Schalke 04 | 1:2 | ||||
| 26. Round | 29/03/2008 | Karlsruher SC | - | FC Schalke 04 | 0:0 | ||||
| 27. Round | 05/04/2008 | FC Schalke 04 | - | Hansa Rostock | 1:0 | ||||
| 28. Round | 12/04/2008 | Werder Bremen | - | FC Schalke 04 | 5:1 | ||||
| 29. Round | 15/04/2008 | FC Schalke 04 | - | Energie Cottbus | 5:0 | ||||
| 34. Round | 17/05/2008 | 1. FC Nürnberg | - | FC Schalke 04 | 0:2 |
Germany