| 1. Round | 16/08/2008 | FC Schalke 04 | - | Hannover 96 | 3:0 | ||||
| 2. Round | 23/08/2008 | Werder Bremen | - | FC Schalke 04 | 1:1 | ||||
| 3. Round | 30/08/2008 | FC Schalke 04 | - | VfL Bochum | 1:0 | ||||
| 4. Round | 13/09/2008 | Borussia Dortmund | - | FC Schalke 04 | 3:3 |  |
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| 6. Round | 26/09/2008 | 1. FC Köln | - | FC Schalke 04 | 1:0 | ||||
| 13. Round | 15/11/2008 | Bayer Leverkusen | - | FC Schalke 04 | 2:1 | ||||
| 14. Round | 22/11/2008 | FC Schalke 04 | - | Bor. Mönchengladbach | 3:1 | ||||
| 15. Round | 30/11/2008 | VfB Stuttgart | - | FC Schalke 04 | 2:0 | ||||
| 20. Round | 14/02/2009 | VfL Bochum | - | FC Schalke 04 | 2:1 | ||||
| 24. Round | 13/03/2009 | VfL Wolfsburg | - | FC Schalke 04 | 4:3 | ||||
| 25. Round | 22/03/2009 | FC Schalke 04 | - | Hamburger SV | 1:2 | ||||
| 26. Round | 03/04/2009 | Arminia Bielefeld | - | FC Schalke 04 | 0:2 | ||||
| 27. Round | 11/04/2009 | FC Schalke 04 | - | Karlsruher SC | 2:0 | ||||
| 28. Round | 17/04/2009 | FC Schalke 04 | - | Energie Cottbus | 4:0 |  |
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| 29. Round | 25/04/2009 | Bayern München | - | FC Schalke 04 | 0:1 | ||||
| 30. Round | 02/05/2009 | FC Schalke 04 | - | Bayer Leverkusen | 1:2 | ||||
| 31. Round | 10/05/2009 | Bor. Mönchengladbach | - | FC Schalke 04 | 1:0 |
Germany