| 16. Round | 29/01/2011 | Bayer Leverkusen II | - | Sportfreunde Lotte | 1:2 | ||||
| 18. Round | 05/02/2011 | Sportfreunde Lotte | - | SV 07 Elversberg | 2:2 | ||||
| 20. Round | 12/02/2011 | Sportfreunde Lotte | - | 1. FC Köln II | 3:1 |  |
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| 21. Round | 19/02/2011 | SC Verl | - | Sportfreunde Lotte | 0:0 |  |
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| 22. Round | 26/02/2011 | Sportfreunde Lotte | - | 1. FC Kaiserslautern II | 1:1 | ||||
| 23. Round | 05/03/2011 | Wuppertaler SV | - | Sportfreunde Lotte | 1:0 | ||||
| 24. Round | 12/03/2011 | Sportfreunde Lotte | - | Preußen Münster | 1:0 | ||||
| 25. Round | 19/03/2011 | Eintracht Trier | - | Sportfreunde Lotte | 1:1 | |
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| 26. Round | 01/04/2011 | Sportfreunde Lotte | - | Arminia Bielefeld II | 0:2 | ||||
| 27. Round | 09/04/2011 | Borussia Dortmund II | - | Sportfreunde Lotte | 1:1 | ||||
| 30. Round | 30/04/2011 | FC Schalke 04 II | - | Sportfreunde Lotte | 0:1 | ||||
| 31. Round | 07/05/2011 | Sportfreunde Lotte | - | VfL Bochum II | 3:0 | |
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| 32. Round | 13/05/2011 | SC Wiedenbrück | - | Sportfreunde Lotte | 1:1 | ||||
| 33. Round | 21/05/2011 | Sportfreunde Lotte | - | Bayer Leverkusen II | 1:0 | |
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| 34. Round | 28/05/2011 | FC 08 Homburg | - | Sportfreunde Lotte | 1:2 |
Germany