| 2. Round | 23/08/2008 | 1899 Hoffenheim | - | Bor. Mönchengladbach | 1:0 | ||||
| 8. Round | 18/10/2008 | Hannover 96 | - | 1899 Hoffenheim | 2:5 | ||||
| 11. Round | 01/11/2008 | 1899 Hoffenheim | - | Karlsruher SC | 4:1 | ||||
| 12. Round | 09/11/2008 | Hertha BSC | - | 1899 Hoffenheim | 1:0 | ||||
| 14. Round | 22/11/2008 | 1. FC Köln | - | 1899 Hoffenheim | 1:3 | ||||
| 15. Round | 29/11/2008 | 1899 Hoffenheim | - | Arminia Bielefeld | 3:0 | ||||
| 23. Round | 07/03/2009 | 1899 Hoffenheim | - | Werder Bremen | 0:0 | ||||
| 24. Round | 14/03/2009 | Eintracht Frankfurt | - | 1899 Hoffenheim | 1:1 | ||||
| 26. Round | 04/04/2009 | Hamburger SV | - | 1899 Hoffenheim | 1:0 |  |
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| 27. Round | 11/04/2009 | 1899 Hoffenheim | - | VfL Bochum | 0:3 | |
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| 28. Round | 18/04/2009 | Karlsruher SC | - | 1899 Hoffenheim | 2:2 | ||||
| 29. Round | 24/04/2009 | 1899 Hoffenheim | - | Hertha BSC | 0:1 | ||||
| 30. Round | 02/05/2009 | VfL Wolfsburg | - | 1899 Hoffenheim | 4:0 | |
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| 31. Round | 09/05/2009 | 1899 Hoffenheim | - | 1. FC Köln | 2:0 | ||||
| 32. Round | 13/05/2009 | Arminia Bielefeld | - | 1899 Hoffenheim | 0:2 | |
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| 33. Round | 16/05/2009 | 1899 Hoffenheim | - | Bayern München | 2:2 | ||||
| 34. Round | 23/05/2009 | FC Schalke 04 | - | 1899 Hoffenheim | 2:3 |
Germany