| 1. Round | 21/08/2010 | Hamburger SV | - | FC Schalke 04 | 2:1 | ||||
| 3. Round | 10/09/2010 | 1899 Hoffenheim | - | FC Schalke 04 | 2:0 | ||||
| 4. Round | 19/09/2010 | FC Schalke 04 | - | Borussia Dortmund | 1:3 | ||||
| 5. Round | 22/09/2010 | SC Freiburg | - | FC Schalke 04 | 1:2 | ||||
| 8. Round | 16/10/2010 | FC Schalke 04 | - | VfB Stuttgart | 2:2 | ||||
| 9. Round | 23/10/2010 | Eintracht Frankfurt | - | FC Schalke 04 | 0:0 | ||||
| 11. Round | 05/11/2010 | FC Schalke 04 | - | FC St. Pauli | 3:0 | ||||
| 12. Round | 13/11/2010 | VfL Wolfsburg | - | FC Schalke 04 | 2:2 | ||||
| 13. Round | 20/11/2010 | FC Schalke 04 | - | Werder Bremen | 4:0 | ||||
| 18. Round | 15/01/2011 | FC Schalke 04 | - | Hamburger SV | 0:1 | ||||
| 19. Round | 22/01/2011 | Hannover 96 | - | FC Schalke 04 | 0:1 | ||||
| 20. Round | 29/01/2011 | FC Schalke 04 | - | 1899 Hoffenheim | 0:1 |  |
Germany