| 1. Round | 13/08/2021 | Schwarz-Weiß Rehden | - | HSC Hannover | 1:1 | ||||
| 2. Round | 22/08/2021 | HSC Hannover | - | Lüneburger SK Hansa | 0:2 | ||||
| 4. Round | 04/09/2021 | HSC Hannover | - | FC Oberneuland | 1:0 | ||||
| 6. Round | 19/09/2021 | VfV Hildesheim | - | HSC Hannover | 3:1 | ||||
| 7. Round | 25/09/2021 | SSV Jeddeloh II | - | HSC Hannover | 1:1 | ||||
| 5. Round | 29/09/2021 | Hannover 96 II | - | HSC Hannover | 2:1 | ||||
| 10. Round | 17/10/2021 | HSC Hannover | - | Schwarz-Weiß Rehden | 2:1 | ||||
| 11. Round | 24/10/2021 | Lüneburger SK Hansa | - | HSC Hannover | 1:0 | ||||
| 13. Round | 06/11/2021 | FC Oberneuland | - | HSC Hannover | 1:1 | ||||
| 14. Round | 14/11/2021 | HSC Hannover | - | Hannover 96 II | 1:5 | ||||
| 12. Round | 24/11/2021 | Werder Bremen II | - | HSC Hannover | 2:0 | ||||
| 16. Round | 28/11/2021 | HSC Hannover | - | SSV Jeddeloh II | 1:5 | ||||
| 17. Round | 05/12/2021 | HSC Hannover | - | Atlas Delmenhorst | 3:1 |  |
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| 18. Round | 12/12/2021 | VfB Oldenburg | - | HSC Hannover | 7:1 | |
Germany