| 1. Round | 15/08/2021 | Hamburger SV [Youth B] | - | Energie Cottbus [Youth B] | 3:1 | ||||
| 2. Round | 21/08/2021 | Energie Cottbus [Youth B] | - | Hertha Zehlendorf [Youth B] | 2:1 |  |
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| 4. Round | 11/09/2021 | Energie Cottbus [Youth B] | - | Chemnitzer FC [Youth B] | 0:1 | ||||
| 6. Round | 25/09/2021 | Energie Cottbus [Youth B] | - | Hallescher FC [Youth B] | 1:2 | ||||
| 7. Round | 02/10/2021 | 1. FC Union Berlin [Youth B] | - | Energie Cottbus [Youth B] | 3:1 | ||||
| 9. Round | 16/10/2021 | Dynamo Dresden [Youth B] | - | Energie Cottbus [Youth B] | 5:0 | ||||
| 10. Round | 06/11/2021 | Energie Cottbus [Youth B] | - | FC Viktoria 1889 Berlin [Youth B] | 2:1 | ||||
| 3. Round | 13/11/2021 | Hansa Rostock [Youth B] | - | Energie Cottbus [Youth B] | 5:2 | ||||
| 11. Round | 20/11/2021 | Erzgebirge Aue [Youth B] | - | Energie Cottbus [Youth B] | 2:2 | ||||
| 17. Round | 02/04/2022 | Energie Cottbus [Youth B] | - | Eintracht Braunschweig [Youth B] | 3:0 |  |
Germany