| 1. Round | 29/08/2021 | SV Schermbeck | - | Westfalia Herne | 6:0 | ||||
| 3. Round | 12/09/2021 | FCE Rheine | - | Westfalia Herne | 1:0 | ||||
| 4. Round | 19/09/2021 | Westfalia Herne | - | TSG Sprockhövel | 1:1 | ||||
| 5. Round | 26/09/2021 | Hammer SpVg | - | Westfalia Herne | 4:0 | ||||
| 6. Round | 03/10/2021 | Westfalia Herne | - | Sportfreunde Siegen | 0:2 | ||||
| 7. Round | 10/10/2021 | SpVgg Vreden | - | Westfalia Herne | 3:2 | ||||
| 8. Round | 17/10/2021 | Westfalia Herne | - | FC Gütersloh | 1:2 | ||||
| 9. Round | 24/10/2021 | TuS Haltern | - | Westfalia Herne | 2:1 | ||||
| 10. Round | 31/10/2021 | Westfalia Herne | - | TuS Erndtebrück | 2:4 | ||||
| 11. Round | 07/11/2021 | Preußen Münster II | - | Westfalia Herne | 2:2 | ||||
| 12. Round | 14/11/2021 | Westfalia Herne | - | SC Paderborn 07 II | 1:2 | ||||
| 13. Round | 20/11/2021 | RSV Meinerzhagen | - | Westfalia Herne | 4:2 | ||||
| 15. Round | 05/12/2021 | Westfalia Herne | - | Westfalia Rhynern | 2:0 | ||||
| 16. Round | 12/12/2021 | Holzwickeder SC | - | Westfalia Herne | 1:1 |
Germany
Angola