| 23. Round | 03/03/2018 | FSC Lohfelden | - | SpVgg Neu-Isenburg | 0:1 | ||||
| 24. Round | 09/03/2018 | Hessen Dreieich | - | SpVgg Neu-Isenburg | 2:1 | ||||
| 26. Round | 24/03/2018 | SV Buchonia Flieden | - | SpVgg Neu-Isenburg | 2:1 | ||||
| 22. Round | 29/03/2018 | SpVgg Neu-Isenburg | - | Borussia Fulda | 0:0 |  |
|||
| 29. Round | 22/04/2018 | SpVgg Neu-Isenburg | - | Viktoria Griesheim | 2:0 | ||||
| 30. Round | 28/04/2018 | SV Rot-Weiss Hadamar | - | SpVgg Neu-Isenburg | 4:0 | ||||
| 31. Round | 06/05/2018 | SpVgg Neu-Isenburg | - | Bayern Alzenau | 1:1 | ||||
| 32. Round | 12/05/2018 | Rot-Weiss Frankfurt | - | SpVgg Neu-Isenburg | 2:2 | ||||
| 33. Round | 20/05/2018 | SpVgg Neu-Isenburg | - | VfB Ginsheim | 1:4 | ||||
| 34. Round | 26/05/2018 | OSC Vellmar | - | SpVgg Neu-Isenburg | 1:2 |
France