| 2. Round | 05/09/2021 | Holzwickeder SC | - | TuS Ennepetal | 2:4 | ||||
| 6. Round | 03/10/2021 | Holzwickeder SC | - | TSG Sprockhövel | 0:5 | ||||
| 9. Round | 24/10/2021 | SpVgg Vreden | - | Holzwickeder SC | 1:0 | ||||
| 17. Round | 09/03/2022 | Westfalia Rhynern | - | Holzwickeder SC | 2:0 | ||||
| 19. Round | 13/03/2022 | Holzwickeder SC | - | ASC 09 Dortmund | 1:5 |  |
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| 20. Round | 20/03/2022 | SG Finnentrop/Bamenohl | - | Holzwickeder SC | 2:0 | ||||
| 21. Round | 07/04/2022 | Holzwickeder SC | - | 1. FC Kaan-Marienborn | 1:1 |
Germany