| 11. Round | 06/11/2021 | RB Leipzig | - | Borussia Dortmund | 2:1 | ||||
| 13. Round | 27/11/2021 | VfL Wolfsburg | - | Borussia Dortmund | 1:3 | ||||
| 15. Round | 11/12/2021 | VfL Bochum | - | Borussia Dortmund | 1:1 |  |
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| 16. Round | 15/12/2021 | Borussia Dortmund | - | SpVgg Greuther Fürth | 3:0 | ||||
| 17. Round | 18/12/2021 | Hertha BSC | - | Borussia Dortmund | 3:2 | ||||
| 20. Round | 22/01/2022 | 1899 Hoffenheim | - | Borussia Dortmund | 2:3 | ||||
| 21. Round | 06/02/2022 | Borussia Dortmund | - | Bayer Leverkusen | 2:5 | ||||
| 22. Round | 13/02/2022 | 1. FC Union Berlin | - | Borussia Dortmund | 0:3 | ||||
| 23. Round | 20/02/2022 | Borussia Dortmund | - | Bor. Mönchengladbach | 6:0 | |
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| 29. Round | 08/04/2022 | VfB Stuttgart | - | Borussia Dortmund | 0:2 | ||||
| 30. Round | 16/04/2022 | Borussia Dortmund | - | VfL Wolfsburg | 6:1 | ||||
| 31. Round | 23/04/2022 | Bayern München | - | Borussia Dortmund | 3:1 | ||||
| 32. Round | 30/04/2022 | Borussia Dortmund | - | VfL Bochum | 3:4 | ||||
| 33. Round | 07/05/2022 | SpVgg Greuther Fürth | - | Borussia Dortmund | 1:3 | ||||
| 34. Round | 14/05/2022 | Borussia Dortmund | - | Hertha BSC | 2:1 |
France
Ivory Coast 