6. Round | 25/09/2021 | Bayer Leverkusen | - | 1. FSV Mainz 05 | 1:0 | ||||
7. Round | 03/10/2021 | 1. FSV Mainz 05 | - | 1. FC Union Berlin | 1:2 | ||||
9. Round | 22/10/2021 | 1. FSV Mainz 05 | - | FC Augsburg | 4:1 | ||||
16. Round | 14/12/2021 | 1. FSV Mainz 05 | - | Hertha BSC | 4:0 | ||||
17. Round | 18/12/2021 | Eintracht Frankfurt | - | 1. FSV Mainz 05 | 1:0 | ||||
18. Round | 08/01/2022 | RB Leipzig | - | 1. FSV Mainz 05 | 4:1 | ||||
20. Round | 22/01/2022 | SpVgg Greuther Fürth | - | 1. FSV Mainz 05 | 2:1 | ||||
25. Round | 16/03/2022 | 1. FSV Mainz 05 | - | Borussia Dortmund | 0:1 | ||||
29. Round | 09/04/2022 | 1. FC Köln | - | 1. FSV Mainz 05 | 3:2 | ||||
32. Round | 30/04/2022 | 1. FSV Mainz 05 | - | Bayern München | 3:1 | ||||
34. Round | 14/05/2022 | 1. FSV Mainz 05 | - | Eintracht Frankfurt | 2:2 |