| 21. Round | 06/02/2022 | Holstein Kiel | - | Fortuna Düsseldorf | 1:0 | ||||
| 22. Round | 13/02/2022 | Fortuna Düsseldorf | - | FC Schalke 04 | 2:1 | ||||
| 23. Round | 20/02/2022 | Fortuna Düsseldorf | - | Erzgebirge Aue | 3:1 |  |
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| 24. Round | 27/02/2022 | Jahn Regensburg | - | Fortuna Düsseldorf | 0:0 | ||||
| 25. Round | 06/03/2022 | Fortuna Düsseldorf | - | FC Ingolstadt 04 | 3:0 | |
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| 27. Round | 19/03/2022 | Fortuna Düsseldorf | - | Hamburger SV | 1:1 | ||||
| 28. Round | 03/04/2022 | Karlsruher SC | - | Fortuna Düsseldorf | 2:2 | |
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| 32. Round | 29/04/2022 | 1. FC Heidenheim 1846 | - | Fortuna Düsseldorf | 1:3 | ||||
| 33. Round | 06/05/2022 | Fortuna Düsseldorf | - | SV Darmstadt 98 | 2:1 |  |
Germany
