| 1. Round | 29/08/2021 | 1. FC Kaan-Marienborn | - | ASC 09 Dortmund | 3:1 |  |
|||
| 2. Round | 05/09/2021 | SG Finnentrop/Bamenohl | - | 1. FC Kaan-Marienborn | 0:6 | |
|||
| 4. Round | 19/09/2021 | 1. FC Kaan-Marienborn | - | Viktoria Clarholz | 3:3 | |
|||
| 5. Round | 26/09/2021 | TuS Ennepetal | - | 1. FC Kaan-Marienborn | 0:3 | ||||
| 9. Round | 24/10/2021 | TSG Sprockhövel | - | 1. FC Kaan-Marienborn | 1:6 | ||||
| 10. Round | 31/10/2021 | 1. FC Kaan-Marienborn | - | Hammer SpVg | 3:0 | ||||
| 11. Round | 07/11/2021 | Sportfreunde Siegen | - | 1. FC Kaan-Marienborn | 3:2 | ||||
| 12. Round | 14/11/2021 | 1. FC Kaan-Marienborn | - | SpVgg Vreden | 1:0 | ||||
| 13. Round | 20/11/2021 | FC Gütersloh | - | 1. FC Kaan-Marienborn | 1:2 | |
|||
| 14. Round | 28/11/2021 | 1. FC Kaan-Marienborn | - | TuS Haltern | 3:0 | ||||
| 15. Round | 05/12/2021 | TuS Erndtebrück | - | 1. FC Kaan-Marienborn | 2:1 | ||||
| 16. Round | 12/12/2021 | 1. FC Kaan-Marienborn | - | Preußen Münster II | 1:1 | |
|||
| 17. Round | 20/02/2022 | SC Paderborn 07 II | - | 1. FC Kaan-Marienborn | 1:1 | ||||
| 18. Round | 06/03/2022 | 1. FC Kaan-Marienborn | - | RSV Meinerzhagen | 1:0 |  |
|||
| 21. Round | 07/04/2022 | Holzwickeder SC | - | 1. FC Kaan-Marienborn | 1:1 |
Germany