| 1. Round | 23/07/2022 | Rot-Weiss Essen | - | SV 07 Elversberg | 1:5 |  |
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| 2. Round | 05/08/2022 | MSV Duisburg | - | Rot-Weiss Essen | 2:2 | ||||
| 3. Round | 09/08/2022 | Rot-Weiss Essen | - | Viktoria Köln | 1:4 | ||||
| 4. Round | 13/08/2022 | Borussia Dortmund II | - | Rot-Weiss Essen | 1:0 | ||||
| 5. Round | 20/08/2022 | Rot-Weiss Essen | - | FC Ingolstadt 04 | 2:2 | ||||
| 6. Round | 27/08/2022 | SpVgg Bayreuth | - | Rot-Weiss Essen | 1:1 | |
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| 7. Round | 02/09/2022 | Rot-Weiss Essen | - | Erzgebirge Aue | 2:1 | ||||
| 8. Round | 09/09/2022 | VfL Osnabrück | - | Rot-Weiss Essen | 1:0 | ||||
| 10. Round | 02/10/2022 | SV Wehen Wiesbaden | - | Rot-Weiss Essen | 3:1 | ||||
| 11. Round | 09/10/2022 | SC Freiburg II | - | Rot-Weiss Essen | 0:3 | ||||
| 12. Round | 15/10/2022 | Rot-Weiss Essen | - | Dynamo Dresden | 1:1 | ||||
| 13. Round | 22/10/2022 | Waldhof Mannheim | - | Rot-Weiss Essen | 1:2 | ||||
| 14. Round | 29/10/2022 | Rot-Weiss Essen | - | FSV Zwickau | 1:1 | ||||
| 15. Round | 06/11/2022 | VfB Oldenburg | - | Rot-Weiss Essen | 3:5 | ||||
| 16. Round | 09/11/2022 | Rot-Weiss Essen | - | SV Meppen | 0:0 | ||||
| 17. Round | 14/11/2022 | TSV 1860 München | - | Rot-Weiss Essen | 1:1 | ||||
| 19. Round | 21/01/2023 | SC Verl | - | Rot-Weiss Essen | 1:1 |
Germany
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