| 7. Round | 15/09/2012 | Bayer Leverkusen II | - | Sportfreunde Lotte | 3:1 | ||||
| 11. Round | 05/10/2012 | Bayer Leverkusen II | - | SC Verl | 3:1 |  |
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| 12. Round | 20/10/2012 | 1. FC Köln II | - | Bayer Leverkusen II | 1:1 | ||||
| 14. Round | 04/11/2012 | Fortuna Düsseldorf II | - | Bayer Leverkusen II | 1:2 | ||||
| 15. Round | 09/11/2012 | Bayer Leverkusen II | - | SV Bergisch Gladbach 09 | 1:2 | ||||
| 16. Round | 17/11/2012 | VfB Hüls | - | Bayer Leverkusen II | 2:3 | ||||
| 17. Round | 23/11/2012 | Rot-Weiß Oberhausen | - | Bayer Leverkusen II | 2:1 | ||||
| 19. Round | 01/12/2012 | FC Schalke 04 II | - | Bayer Leverkusen II | 0:0 | ||||
| 21. Round | 12/12/2012 | Bayer Leverkusen II | - | Viktoria Köln | 2:3 |
Germany