| 21. Round | 27/07/2018 | FC Eddersheim | - | SpVgg Neu-Isenburg | 2:1 | ||||
| 1. Round | 05/08/2018 | Türk Gücü Friedberg | - | SpVgg Neu-Isenburg | 2:2 |  |
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| 7. Round | 11/08/2018 | SpVgg Neu-Isenburg | - | Hessen Kassel | 0:2 | ||||
| 4. Round | 19/08/2018 | FC Ederbergland | - | SpVgg Neu-Isenburg | 1:4 | ||||
| 5. Round | 26/08/2018 | SpVgg Neu-Isenburg | - | FC Eddersheim | 1:3 | ||||
| 6. Round | 01/09/2018 | Hünfelder SV | - | SpVgg Neu-Isenburg | 0:2 | |
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| 8. Round | 09/09/2018 | SpVgg Neu-Isenburg | - | FSC Lohfelden | 4:1 | ||||
| 9. Round | 15/09/2018 | FC Gießen | - | SpVgg Neu-Isenburg | 4:1 | ||||
| 13. Round | 06/10/2018 | FV Bad Vilbel | - | SpVgg Neu-Isenburg | 1:1 | ||||
| 15. Round | 20/10/2018 | SV Rot-Weiss Hadamar | - | SpVgg Neu-Isenburg | 9:0 | ||||
| 16. Round | 28/10/2018 | SpVgg Neu-Isenburg | - | SG Barockstadt Fulda-Lehnerz | 1:5 | ||||
| 20. Round | 25/11/2018 | SpVgg Neu-Isenburg | - | FC Ederbergland | 0:1 | ||||
| 3. Round | 01/12/2018 | SV Buchonia Flieden | - | SpVgg Neu-Isenburg | 3:0 | |
Germany