| 2. Round | 21/08/2021 | RB Leipzig [Youth B] | - | Chemnitzer FC [Youth B] | 1:2 | ||||
| 5. Round | 18/09/2021 | Chemnitzer FC [Youth B] | - | Hertha BSC [Youth B] | 0:4 |  |
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| 7. Round | 02/10/2021 | Chemnitzer FC [Youth B] | - | Eintracht Braunschweig [Youth B] | 2:1 | ||||
| 8. Round | 09/10/2021 | Werder Bremen [Youth B] | - | Chemnitzer FC [Youth B] | 2:3 | ||||
| 10. Round | 06/11/2021 | Hamburger SV [Youth B] | - | Chemnitzer FC [Youth B] | 1:0 | ||||
| 12. Round | 27/11/2021 | Hansa Rostock [Youth B] | - | Chemnitzer FC [Youth B] | 0:2 | |
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| 14. Round | 26/02/2022 | Chemnitzer FC [Youth B] | - | FC Carl Zeiss Jena [Youth B] | 2:1 | ||||
| 15. Round | 05/03/2022 | Hallescher FC [Youth B] | - | Chemnitzer FC [Youth B] | 0:2 | |
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| 16. Round | 12/03/2022 | Chemnitzer FC [Youth B] | - | 1. FC Union Berlin [Youth B] | 0:1 | ||||
| 11. Round | 19/03/2022 | Chemnitzer FC [Youth B] | - | Hertha Zehlendorf [Youth B] | 4:0 | ||||
| 17. Round | 26/03/2022 | Hannover 96 [Youth B] | - | Chemnitzer FC [Youth B] | 2:1 |  |
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| 18. Round | 09/04/2022 | Chemnitzer FC [Youth B] | - | Dynamo Dresden [Youth B] | 1:0 | ||||
| 19. Round | 23/04/2022 | FC Viktoria 1889 Berlin [Youth B] | - | Chemnitzer FC [Youth B] | 3:0 |
Germany