| 21. Round | 27/01/2012 | Sportfreunde Lotte | - | FC Schalke 04 II | 2:0 | ||||
| 26. Round | 03/03/2012 | Borussia Dortmund II | - | FC Schalke 04 II | 2:1 | ||||
| 20. Round | 06/03/2012 | FC Schalke 04 II | - | Bayer Leverkusen II | 1:1 | ||||
| 27. Round | 10/03/2012 | FC Schalke 04 II | - | Fortuna Düsseldorf II | 2:0 | ||||
| 28. Round | 17/03/2012 | Fortuna Köln | - | FC Schalke 04 II | 2:1 | ||||
| 24. Round | 20/03/2012 | FC Schalke 04 II | - | SC 07 Idar-Oberstein | 1:0 | ||||
| 29. Round | 24/03/2012 | FC Schalke 04 II | - | 1. FSV Mainz 05 II | 1:1 | ||||
| 23. Round | 27/03/2012 | SC Wiedenbrück | - | FC Schalke 04 II | 3:5 | ||||
| 30. Round | 01/04/2012 | 1. FC Köln II | - | FC Schalke 04 II | 4:2 | ||||
| 31. Round | 07/04/2012 | FC Schalke 04 II | - | SV 07 Elversberg | 4:0 | ||||
| 32. Round | 10/04/2012 | TuS Koblenz | - | FC Schalke 04 II | 0:2 |  |
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| 33. Round | 14/04/2012 | FC Schalke 04 II | - | SC Verl | 1:2 |  |
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| 22. Round | 17/04/2012 | FC Schalke 04 II | - | Eintracht Trier | 1:2 | |
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| 35. Round | 28/04/2012 | FC Schalke 04 II | - | Rot-Weiss Essen | 2:3 | |
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| 36. Round | 05/05/2012 | VfL Bochum II | - | FC Schalke 04 II | 1:4 | |
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| 38. Round | 19/05/2012 | 1. FC Kaiserslautern II | - | FC Schalke 04 II | 0:0 |
Germany