| 30. Round | 19/03/2022 | Rot-Weiss Essen | - | KFC Uerdingen 05 | 3:0 | ||||
| 31. Round | 26/03/2022 | SC Wiedenbrück | - | Rot-Weiss Essen | 0:1 | ||||
| 34. Round | 16/04/2022 | Rot-Weiss Essen | - | Bor. Mönchengladbach II | 1:1 | ||||
| 35. Round | 22/04/2022 | Sportfreunde Lotte | - | Rot-Weiss Essen | 0:3 |  |
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| 36. Round | 29/04/2022 | Rot-Weiss Essen | - | FC Wegberg-Beeck | 3:1 |
Germany