| 17. Round | 13/12/1980 | 1. FC Köln | - | FC Schalke 04 | 0:2 |  |
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| 19. Round | 24/01/1981 | FC Schalke 04 | - | Bor. Mönchengladbach | 2:2 | ||||
| 18. Round | 27/01/1981 | Eintracht Frankfurt | - | FC Schalke 04 | 5:0 | ||||
| 21. Round | 14/02/1981 | FC Schalke 04 | - | Bayern München | 2:2 | ||||
| 25. Round | 21/03/1981 | Arminia Bielefeld | - | FC Schalke 04 | 1:0 | ||||
| 27. Round | 04/04/1981 | VfB Stuttgart | - | FC Schalke 04 | 3:0 | ||||
| 29. Round | 18/04/1981 | TSV 1860 München | - | FC Schalke 04 | 3:1 |  |
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| 32. Round | 30/05/1981 | FC Schalke 04 | - | 1. FC Nürnberg | 1:1 | |
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| 33. Round | 06/06/1981 | 1. FC Kaiserslautern | - | FC Schalke 04 | 2:0 | ||||
| 34. Round | 13/06/1981 | FC Schalke 04 | - | 1. FC Köln | 1:2 |
Germany