| 6. Round | 26/09/2021 | SSC Napoli | - | Cagliari Calcio | 2:0 | ||||
| 7. Round | 03/10/2021 | ACF Fiorentina | - | SSC Napoli | 1:2 |  |
|||
| 10. Round | 28/10/2021 | SSC Napoli | - | Bologna FC | 3:0 | ||||
| 14. Round | 28/11/2021 | SSC Napoli | - | Lazio Roma | 4:0 | |
|||
| 15. Round | 01/12/2021 | Sassuolo Calcio | - | SSC Napoli | 2:2 | |
|||
| 16. Round | 04/12/2021 | SSC Napoli | - | Atalanta | 2:3 | ||||
| 17. Round | 12/12/2021 | SSC Napoli | - | Empoli FC | 0:1 | ||||
| 18. Round | 19/12/2021 | AC Milan | - | SSC Napoli | 0:1 | ||||
| 19. Round | 22/12/2021 | SSC Napoli | - | Spezia Calcio | 0:1 | ||||
| 20. Round | 06/01/2022 | Juventus | - | SSC Napoli | 1:1 | |
|||
| 21. Round | 09/01/2022 | SSC Napoli | - | Sampdoria | 1:0 | ||||
| 22. Round | 17/01/2022 | Bologna FC | - | SSC Napoli | 0:2 | ||||
| 26. Round | 21/02/2022 | Cagliari Calcio | - | SSC Napoli | 1:1 | ||||
| 27. Round | 27/02/2022 | Lazio Roma | - | SSC Napoli | 1:2 | ||||
| 32. Round | 10/04/2022 | SSC Napoli | - | ACF Fiorentina | 2:3 | ||||
| 33. Round | 18/04/2022 | SSC Napoli | - | AS Roma | 1:1 | ||||
| 35. Round | 30/04/2022 | SSC Napoli | - | Sassuolo Calcio | 6:1 | ||||
| 37. Round | 15/05/2022 | SSC Napoli | - | Genoa CFC | 3:0 | ||||
| 38. Round | 22/05/2022 | Spezia Calcio | - | SSC Napoli | 0:3 |  |
Germany
Italy 
