| 3. Round | 13/09/1980 | BSG Stahl Blankenburg | - | BSG Chemie Wolfen | 1:0 | ||||
| 4. Round | 20/09/1980 | BSG Chemie Wolfen | - | BSG Stahl Thale | 0:1 | ||||
| 5. Round | 04/10/1980 | BSG MK Sangerhausen | - | BSG Chemie Wolfen | 3:2 | ||||
| 6. Round | 07/10/1980 | BSG Chemie Wolfen | - | SG Dynamo Eisleben | 1:1 | ||||
| 7. Round | 19/10/1980 | Chemie Schönebeck | - | BSG Chemie Wolfen | 4:1 | ||||
| 8. Round | 26/10/1980 | BSG Chemie Wolfen | - | BSG Chemie Buna Schkopau | 0:1 | ||||
| 9. Round | 07/11/1980 | BSG Stahl Nordwest Leipzig | - | BSG Chemie Wolfen | 5:1 | ||||
| 10. Round | 15/11/1980 | BSG Chemie Wolfen | - | BSG Lokomotive Stendal | 0:1 | ||||
| 11. Round | 22/11/1980 | ASG Vorwärts Dessau | - | BSG Chemie Wolfen | 3:2 | ||||
| 12. Round | 29/11/1980 | BSG Chemie Zeitz | - | BSG Chemie Wolfen | 3:2 | ||||
| 13. Round | 06/12/1980 | BSG Chemie Wolfen | - | BSG Chemie Leipzig | 2:2 | ||||
| 17. Round | 14/03/1981 | SG Dynamo Eisleben | - | BSG Chemie Wolfen | 2:2 | ||||
| 18. Round | 21/03/1981 | BSG Chemie Wolfen | - | Chemie Schönebeck | 1:0 |  |
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| 19. Round | 28/03/1981 | BSG Chemie Buna Schkopau | - | BSG Chemie Wolfen | 0:0 | ||||
| 20. Round | 03/04/1981 | BSG Chemie Wolfen | - | BSG Stahl Nordwest Leipzig | 6:1 |
Germany