| 1. Round | 25/07/2015 | SpVgg Greuther Fürth | - | Karlsruher SC | 1:0 | ||||
| 2. Round | 02/08/2015 | Karlsruher SC | - | FC St. Pauli | 1:2 | ||||
| 3. Round | 14/08/2015 | FSV Frankfurt | - | Karlsruher SC | 1:2 | ||||
| 4. Round | 22/08/2015 | Karlsruher SC | - | MSV Duisburg | 2:0 | ||||
| 5. Round | 30/08/2015 | Eintracht Braunschweig | - | Karlsruher SC | 6:0 | ||||
| 6. Round | 12/09/2015 | Karlsruher SC | - | 1. FC Union Berlin | 0:3 | ||||
| 7. Round | 19/09/2015 | SC Paderborn 07 | - | Karlsruher SC | 2:0 | ||||
| 8. Round | 22/09/2015 | Karlsruher SC | - | Fortuna Düsseldorf | 1:1 | ||||
| 9. Round | 27/09/2015 | 1. FC Heidenheim 1846 | - | Karlsruher SC | 1:1 | ||||
| 11. Round | 19/10/2015 | TSV 1860 München | - | Karlsruher SC | 0:1 |  |
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| 12. Round | 24/10/2015 | Karlsruher SC | - | 1. FC Kaiserslautern | 2:0 | ||||
| 13. Round | 02/11/2015 | 1. FC Nürnberg | - | Karlsruher SC | 0:0 | ||||
| 14. Round | 06/11/2015 | Karlsruher SC | - | VfL Bochum | 3:0 | ||||
| 15. Round | 20/11/2015 | SV Sandhausen | - | Karlsruher SC | 3:1 | ||||
| 16. Round | 30/11/2015 | Karlsruher SC | - | RB Leipzig | 0:1 | ||||
| 17. Round | 05/12/2015 | Arminia Bielefeld | - | Karlsruher SC | 2:1 |
Germany