| 21. Round | 23/02/2019 | Wormatia Worms | - | 1. FSV Mainz 05 II | 2:1 |  |
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| 23. Round | 08/03/2019 | SV 07 Elversberg | - | 1. FSV Mainz 05 II | 3:1 | ||||
| 24. Round | 12/03/2019 | 1. FSV Mainz 05 II | - | FC-Astoria Walldorf | 1:1 |  |
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| 25. Round | 17/03/2019 | VfB Stuttgart II | - | 1. FSV Mainz 05 II | 1:1 | |
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| 26. Round | 23/03/2019 | SSV Ulm 1846 | - | 1. FSV Mainz 05 II | 1:0 | |
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| 27. Round | 29/03/2019 | 1. FSV Mainz 05 II | - | 1899 Hoffenheim II | 2:2 |  |
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| 28. Round | 05/04/2019 | Hessen Dreieich | - | 1. FSV Mainz 05 II | 1:3 | ||||
| 29. Round | 12/04/2019 | 1. FSV Mainz 05 II | - | FSV Frankfurt | 2:0 | ||||
| 30. Round | 18/04/2019 | SC Freiburg II | - | 1. FSV Mainz 05 II | 2:1 | ||||
| 31. Round | 27/04/2019 | 1. FSV Mainz 05 II | - | 1. FC Saarbrücken | 3:1 | |
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| 32. Round | 04/05/2019 | Eintracht Stadtallendorf | - | 1. FSV Mainz 05 II | 2:1 | ||||
| 33. Round | 11/05/2019 | 1. FSV Mainz 05 II | - | TSV Steinbach Haiger | 2:1 | |
Germany