| 1. Round | 16/08/2015 | 1. FC Bocholt | - | MSV Duisburg II | 0:2 | ||||
| 2. Round | 23/08/2015 | MSV Duisburg II | - | TV Jahn Hiesfeld | 2:2 | ||||
| 3. Round | 26/08/2015 | MSV Duisburg II | - | TSV Meerbusch | 0:1 | ||||
| 5. Round | 06/09/2015 | MSV Duisburg II | - | TuRU Düsseldorf | 0:2 | ||||
| 6. Round | 13/09/2015 | VfB 03 Hilden | - | MSV Duisburg II | 0:1 | ||||
| 7. Round | 20/09/2015 | MSV Duisburg II | - | SV Hönnepel-Niedermörmter | 3:0 | ||||
| 8. Round | 23/09/2015 | SC Düsseldorf-West | - | MSV Duisburg II | 0:3 | ||||
| 9. Round | 26/09/2015 | MSV Duisburg II | - | 1. FC Mönchengladbach | 1:1 | ||||
| 10. Round | 04/10/2015 | KFC Uerdingen 05 | - | MSV Duisburg II | 2:0 | ||||
| 12. Round | 18/10/2015 | MSV Duisburg II | - | Schwarz-Weiß Essen | 1:2 |  |
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| 14. Round | 08/11/2015 | Wuppertaler SV | - | MSV Duisburg II | 2:0 | ||||
| 16. Round | 29/11/2015 | VfR Krefeld-Fischeln | - | MSV Duisburg II | 1:0 | ||||
| 17. Round | 06/12/2015 | MSV Duisburg II | - | TV Kalkum-Wittlaer | 0:0 | ||||
| 20. Round | 06/03/2016 | MSV Duisburg II | - | Germania Ratingen 04/19 | 0:0 | ||||
| 21. Round | 13/03/2016 | TuRU Düsseldorf | - | MSV Duisburg II | 1:0 | ||||
| 24. Round | 28/03/2016 | MSV Duisburg II | - | SC Düsseldorf-West | 4:1 |
Germany