| 10. Round | 20/11/2021 | 1. FC Saarbrücken [Youth] | - | 1899 Hoffenheim [Youth] | 1:3 | ||||
| 11. Round | 28/11/2021 | Hessen Kassel [Youth] | - | 1. FC Saarbrücken [Youth] | 0:2 | ||||
| 12. Round | 04/12/2021 | 1. FC Saarbrücken [Youth] | - | 1. FC Nürnberg [Youth] | 0:1 | ||||
| 13. Round | 05/02/2022 | SpVgg Greuther Fürth [Youth] | - | 1. FC Saarbrücken [Youth] | 1:2 | ||||
| 14. Round | 13/02/2022 | 1. FC Saarbrücken [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:2 | ||||
| 15. Round | 19/02/2022 | Karlsruher SC [Youth] | - | 1. FC Saarbrücken [Youth] | 3:1 | ||||
| 18. Round | 03/04/2022 | 1. FC Saarbrücken [Youth] | - | SpVgg Unterhaching [Youth] | 2:1 | ||||
| 19. Round | 20/04/2022 | 1. FC Kaiserslautern [Youth] | - | 1. FC Saarbrücken [Youth] | 5:0 | ||||
| 20. Round | 23/04/2022 | 1. FC Saarbrücken [Youth] | - | Stuttgarter Kickers [Youth] | 1:0 |  |
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| 21. Round | 30/04/2022 | SV Darmstadt 98 [Youth] | - | 1. FC Saarbrücken [Youth] | 0:2 |
Germany