| 1. Round | 25/07/2021 | Piast Gliwice | - | Raków Częstochowa | 2:3 | ||||
| 2. Round | 31/07/2021 | FKS Stal Mielec | - | Piast Gliwice | 0:2 | ||||
| 3. Round | 08/08/2021 | Pogoń Szczecin | - | Piast Gliwice | 1:0 | ||||
| 5. Round | 22/08/2021 | Piast Gliwice | - | Śląsk Wrocław | 1:1 | ||||
| 7. Round | 12/09/2021 | Piast Gliwice | - | Zagłębie Lubin | 0:1 |  |
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| 8. Round | 18/09/2021 | Lechia Gdańsk | - | Piast Gliwice | 1:0 | ||||
| 9. Round | 27/09/2021 | Piast Gliwice | - | KS Cracovia | 2:4 | ||||
| 10. Round | 01/10/2021 | Piast Gliwice | - | Wisła Kraków | 1:0 | ||||
| 11. Round | 16/10/2021 | Górnik Łęczna | - | Piast Gliwice | 1:1 | |
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| 15. Round | 20/11/2021 | Lech Poznań | - | Piast Gliwice | 1:0 | ||||
| 16. Round | 26/11/2021 | Piast Gliwice | - | Bruk-Bet Termalica Nieciecza | 2:1 | ||||
| 19. Round | 18/12/2021 | Piast Gliwice | - | FKS Stal Mielec | 1:1 |
Poland