| 9. Round | 31/10/2021 | 1. FSV Mainz 05 [Youth] | - | Kickers Offenbach [Youth] | 4:0 | ||||
| 10. Round | 20/11/2021 | Kickers Offenbach [Youth] | - | Karlsruher SC [Youth] | 5:1 |  |
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| 11. Round | 28/11/2021 | FC-Astoria Walldorf [Youth] | - | Kickers Offenbach [Youth] | 5:0 | ||||
| 13. Round | 06/02/2022 | SpVgg Unterhaching [Youth] | - | Kickers Offenbach [Youth] | 3:0 | ||||
| 14. Round | 13/02/2022 | Kickers Offenbach [Youth] | - | 1. FC Kaiserslautern [Youth] | 1:2 | ||||
| 15. Round | 20/02/2022 | Stuttgarter Kickers [Youth] | - | Kickers Offenbach [Youth] | 0:3 | ||||
| 16. Round | 26/02/2022 | Kickers Offenbach [Youth] | - | SV Darmstadt 98 [Youth] | 0:4 | ||||
| 12. Round | 01/03/2022 | Kickers Offenbach [Youth] | - | FC Ingolstadt 04 [Youth] | 1:1 | ||||
| 19. Round | 09/04/2022 | Kickers Offenbach [Youth] | - | SC Freiburg [Youth] | 0:2 |
South Korea