| 1. Round | 11/09/2021 | SC Paderborn 07 [Youth] | - | Wuppertaler SV [Youth] | 1:1 |  |
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| 2. Round | 19/09/2021 | Wuppertaler SV [Youth] | - | Fortuna Köln [Youth] | 2:1 | ||||
| 3. Round | 26/09/2021 | MSV Duisburg [Youth] | - | Wuppertaler SV [Youth] | 0:1 | ||||
| 6. Round | 24/10/2021 | Wuppertaler SV [Youth] | - | 1. FC Köln [Youth] | 0:4 | ||||
| 11. Round | 13/02/2022 | Wuppertaler SV [Youth] | - | Borussia Dortmund [Youth] | 0:4 | ||||
| 12. Round | 20/02/2022 | Viktoria Köln [Youth] | - | Wuppertaler SV [Youth] | 4:0 | ||||
| 13. Round | 05/03/2022 | Wuppertaler SV [Youth] | - | Bor. Mönchengladbach [Youth] | 1:1 | ||||
| 15. Round | 09/04/2022 | Wuppertaler SV [Youth] | - | Preußen Münster [Youth] | 0:3 | ||||
| 16. Round | 23/04/2022 | Rot-Weiss Essen [Youth] | - | Wuppertaler SV [Youth] | 2:1 | ||||
| 17. Round | 30/04/2022 | Wuppertaler SV [Youth] | - | Rot-Weiß Oberhausen [Youth] | 4:1 |  |
Germany