| 2. Round | 01/09/2020 | SV 07 Elversberg | - | FC Gießen | 1:0 | ||||
| 3. Round | 12/09/2020 | FC Gießen | - | Rot-Weiß Koblenz | 3:2 | ||||
| 4. Round | 19/09/2020 | FSV Frankfurt | - | FC Gießen | 1:0 |  |
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| 8. Round | 10/10/2020 | Bahlinger SC | - | FC Gießen | 3:1 |  |
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| 5. Round | 14/10/2020 | FC-Astoria Walldorf | - | FC Gießen | 1:2 | ||||
| 9. Round | 17/10/2020 | FC Gießen | - | SG Sonnenhof Großaspach | 1:1 | ||||
| 10. Round | 20/10/2020 | Kickers Offenbach | - | FC Gießen | 1:0 | |
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| 19. Round | 12/12/2020 | TSV Schott Mainz | - | FC Gießen | 0:2 | |
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| 14. Round | 15/12/2020 | SC Freiburg II | - | FC Gießen | 3:0 | ||||
| 20. Round | 19/12/2020 | FC Gießen | - | Eintracht Stadtallendorf | 1:1 | ||||
| 13. Round | 09/01/2021 | FC Gießen | - | TSV Steinbach Haiger | 2:1 | ||||
| 7. Round | 12/01/2021 | 1. FSV Mainz 05 II | - | FC Gießen | 2:1 | ||||
| 15. Round | 16/01/2021 | FC Gießen | - | Bayern Alzenau | 1:0 | ||||
| 16. Round | 20/01/2021 | SSV Ulm 1846 | - | FC Gießen | 2:3 | |
Germany