| 3. Round | 11/09/2021 | VfB Stuttgart [Youth] | - | Kickers Offenbach [Youth] | 3:0 | ||||
| 4. Round | 18/09/2021 | Kickers Offenbach [Youth] | - | Eintracht Frankfurt [Youth] | 0:3 | ||||
| 5. Round | 25/09/2021 | 1899 Hoffenheim [Youth] | - | Kickers Offenbach [Youth] | 6:1 | ||||
| 6. Round | 02/10/2021 | Kickers Offenbach [Youth] | - | Hessen Kassel [Youth] | 3:0 | ||||
| 7. Round | 16/10/2021 | 1. FC Nürnberg [Youth] | - | Kickers Offenbach [Youth] | 3:0 |  |
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| 8. Round | 23/10/2021 | Kickers Offenbach [Youth] | - | SpVgg Greuther Fürth [Youth] | 2:3 | ||||
| 9. Round | 31/10/2021 | 1. FSV Mainz 05 [Youth] | - | Kickers Offenbach [Youth] | 4:0 | ||||
| 10. Round | 20/11/2021 | Kickers Offenbach [Youth] | - | Karlsruher SC [Youth] | 5:1 | ||||
| 11. Round | 28/11/2021 | FC-Astoria Walldorf [Youth] | - | Kickers Offenbach [Youth] | 5:0 | ||||
| 15. Round | 20/02/2022 | Stuttgarter Kickers [Youth] | - | Kickers Offenbach [Youth] | 0:3 | ||||
| 20. Round | 23/04/2022 | SSV Ulm 1846 [Youth] | - | Kickers Offenbach [Youth] | 2:1 | ||||
| 21. Round | 30/04/2022 | Kickers Offenbach [Youth] | - | Bayern München [Youth] | 3:2 |
Germany