| 18. Round | 17/01/2010 | TuS Koblenz | - | TSV 1860 München | 2:2 | ||||
| 19. Round | 24/01/2010 | Arminia Bielefeld | - | TuS Koblenz | 4:2 | ||||
| 20. Round | 29/01/2010 | TuS Koblenz | - | Fortuna Düsseldorf | 1:0 | ||||
| 21. Round | 06/02/2010 | Energie Cottbus | - | TuS Koblenz | 1:1 |  |
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| 22. Round | 14/02/2010 | TuS Koblenz | - | Hansa Rostock | 0:0 | ||||
| 23. Round | 19/02/2010 | 1. FC Union Berlin | - | TuS Koblenz | 3:2 | |
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| 24. Round | 27/02/2010 | TuS Koblenz | - | FC Augsburg | 0:1 |  |
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| 25. Round | 05/03/2010 | Rot-Weiß Oberhausen | - | TuS Koblenz | 2:0 | |
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| 26. Round | 12/03/2010 | Rot Weiss Ahlen | - | TuS Koblenz | 0:2 | |
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| 27. Round | 19/03/2010 | TuS Koblenz | - | SpVgg Greuther Fürth | 2:0 | ||||
| 28. Round | 26/03/2010 | MSV Duisburg | - | TuS Koblenz | 4:1 | ||||
| 29. Round | 04/04/2010 | TuS Koblenz | - | SC Paderborn 07 | 2:1 | |
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| 30. Round | 09/04/2010 | Alemannia Aachen | - | TuS Koblenz | 1:1 | ||||
| 31. Round | 16/04/2010 | TuS Koblenz | - | Karlsruher SC | 2:2 | |
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| 32. Round | 23/04/2010 | FC St. Pauli | - | TuS Koblenz | 6:1 | ||||
| 33. Round | 02/05/2010 | TuS Koblenz | - | 1. FC Kaiserslautern | 2:2 | ||||
| 34. Round | 09/05/2010 | FSV Frankfurt | - | TuS Koblenz | 1:1 | |
Albania