| 2. Round | 21/08/2021 | RB Leipzig [Youth] | - | FC St. Pauli [Youth] | 2:2 | ||||
| 3. Round | 11/09/2021 | FC St. Pauli [Youth] | - | Chemnitzer FC [Youth] | 3:0 | ||||
| 5. Round | 25/09/2021 | FC St. Pauli [Youth] | - | Dynamo Dresden [Youth] | 0:1 | ||||
| 7. Round | 16/10/2021 | FC St. Pauli [Youth] | - | Hallescher FC [Youth] | 3:2 | ||||
| 8. Round | 23/10/2021 | VfL Wolfsburg [Youth] | - | FC St. Pauli [Youth] | 2:2 | ||||
| 9. Round | 30/10/2021 | FC St. Pauli [Youth] | - | Werder Bremen [Youth] | 0:1 | ||||
| 10. Round | 20/11/2021 | Hertha BSC [Youth] | - | FC St. Pauli [Youth] | 4:2 | ||||
| 14. Round | 27/02/2022 | Hansa Rostock [Youth] | - | FC St. Pauli [Youth] | 5:1 |  |
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| 15. Round | 05/03/2022 | FC St. Pauli [Youth] | - | Energie Cottbus [Youth] | 0:2 | ||||
| 13. Round | 17/03/2022 | FC St. Pauli [Youth] | - | Hannover 96 [Youth] | 2:1 |
Germany