| 1. Round | 21/07/2012 | 1. FC Heidenheim 1846 | - | Karlsruher SC | 2:2 | ||||
| 2. Round | 28/07/2012 | Karlsruher SC | - | Hallescher FC | 0:0 | ||||
| 3. Round | 04/08/2012 | VfB Stuttgart II | - | Karlsruher SC | 2:0 | ||||
| 6. Round | 25/08/2012 | Karlsruher SC | - | Alemannia Aachen | 0:0 | ||||
| 7. Round | 28/08/2012 | Borussia Dortmund II | - | Karlsruher SC | 0:3 |  |
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| 8. Round | 02/09/2012 | Karlsruher SC | - | 1. FC Saarbrücken | 3:0 | ||||
| 16. Round | 03/11/2012 | Chemnitzer FC | - | Karlsruher SC | 1:2 | ||||
| 17. Round | 10/11/2012 | Karlsruher SC | - | SV Darmstadt 98 | 2:0 | ||||
| 18. Round | 17/11/2012 | Hansa Rostock | - | Karlsruher SC | 0:3 |  |
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| 19. Round | 24/11/2012 | Karlsruher SC | - | SV Wehen Wiesbaden | 4:0 | ||||
| 24. Round | 02/02/2013 | Karlsruher SC | - | Arminia Bielefeld | 0:0 | ||||
| 27. Round | 23/02/2013 | 1. FC Saarbrücken | - | Karlsruher SC | 0:0 | ||||
| 28. Round | 02/03/2013 | Karlsruher SC | - | Kickers Offenbach | 2:1 |
Germany