| 6. Round | 11/09/2021 | TSV Emmelshausen | - | 1. FC Kaiserslautern II | 0:3 |  |
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| 7. Round | 18/09/2021 | 1. FC Kaiserslautern II | - | FC Karbach | 3:1 | ||||
| 8. Round | 22/09/2021 | SV Alemannia Waldalgesheim | - | 1. FC Kaiserslautern II | 1:0 | ||||
| 9. Round | 26/09/2021 | 1. FC Kaiserslautern II | - | FSV Salmrohr | 3:1 | ||||
| 10. Round | 02/10/2021 | Eintracht Trier | - | 1. FC Kaiserslautern II | 4:1 |  |
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| 12. Round | 17/10/2021 | 1. FC Kaiserslautern II | - | Hassia Bingen | 0:3 | |
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| 13. Round | 23/10/2021 | FV Engers 07 | - | 1. FC Kaiserslautern II | 5:0 | |
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| 14. Round | 27/10/2021 | Sportfreunde Eisbachtal | - | 1. FC Kaiserslautern II | 0:0 | ||||
| 15. Round | 30/10/2021 | 1. FC Kaiserslautern II | - | SG Mülheim-Kärlich | 2:1 | ||||
| 16. Round | 07/11/2021 | SV Gonsenheim | - | 1. FC Kaiserslautern II | 1:1 | |
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| 20. Round | 27/11/2021 | FSV Salmrohr | - | 1. FC Kaiserslautern II | 3:1 | |
Germany