| 2. Round | 22/08/2021 | SV Darmstadt 98 [Youth B] | - | Karlsruher SC [Youth B] | 2:1 | ||||
| 3. Round | 28/08/2021 | Karlsruher SC [Youth B] | - | 1. FC Kaiserslautern [Youth B] | 2:0 | ||||
| 9. Round | 30/10/2021 | SV 07 Elversberg [Youth B] | - | Karlsruher SC [Youth B] | 0:7 | ||||
| 13. Round | 05/12/2021 | FSV Frankfurt [Youth B] | - | Karlsruher SC [Youth B] | 3:2 | ||||
| 15. Round | 20/02/2022 | Bayern München [Youth B] | - | Karlsruher SC [Youth B] | 4:4 | ||||
| 16. Round | 27/02/2022 | Karlsruher SC [Youth B] | - | Stuttgarter Kickers [Youth B] | 3:0 |  |
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| 17. Round | 06/03/2022 | FC Augsburg [Youth B] | - | Karlsruher SC [Youth B] | 0:2 | ||||
| 18. Round | 12/03/2022 | Karlsruher SC [Youth B] | - | SpVgg Greuther Fürth [Youth B] | 1:0 | ||||
| 19. Round | 02/04/2022 | FC Ingolstadt 04 [Youth B] | - | Karlsruher SC [Youth B] | 0:2 | ||||
| 20. Round | 16/04/2022 | Karlsruher SC [Youth B] | - | SSV Reutlingen [Youth B] | 0:0 | ||||
| 21. Round | 23/04/2022 | SC Freiburg [Youth B] | - | Karlsruher SC [Youth B] | 2:2 | |
Germany