| 2. Round | 29/08/2021 | RB Leipzig [Women] | - | 1899 Hoffenheim II [Women] | 2:0 | ||||
| 3. Round | 05/09/2021 | Bayern München II [Women] | - | RB Leipzig [Women] | 3:1 | ||||
| 4. Round | 12/09/2021 | RB Leipzig [Women] | - | Eintracht Frankfurt II [Women] | 4:0 |  |
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| 5. Round | 03/10/2021 | SV Meppen [Women] | - | RB Leipzig [Women] | 5:0 | ||||
| 6. Round | 10/10/2021 | RB Leipzig [Women] | - | SG 99 Andernach [Women] | 0:1 | ||||
| 7. Round | 17/10/2021 | Borussia Bocholt [Women] | - | RB Leipzig [Women] | 1:9 | |
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| 8. Round | 07/11/2021 | RB Leipzig [Women] | - | SV 07 Elversberg [Women] | 3:0 | ||||
| 10. Round | 21/11/2021 | 1. FC Nürnberg [Women] | - | RB Leipzig [Women] | 4:3 | ||||
| 12. Round | 12/12/2021 | FSV Gütersloh 2009 [Women] | - | RB Leipzig [Women] | 1:4 |
Germany