| 5. Round | 26/09/2021 | Hammer SpVg | - | Westfalia Herne | 4:0 | ||||
| 6. Round | 03/10/2021 | Westfalia Herne | - | Sportfreunde Siegen | 0:2 | ||||
| 7. Round | 10/10/2021 | SpVgg Vreden | - | Westfalia Herne | 3:2 | ||||
| 8. Round | 17/10/2021 | Westfalia Herne | - | FC Gütersloh | 1:2 | ||||
| 13. Round | 20/11/2021 | RSV Meinerzhagen | - | Westfalia Herne | 4:2 | ||||
| 15. Round | 05/12/2021 | Westfalia Herne | - | Westfalia Rhynern | 2:0 | ||||
| 16. Round | 12/12/2021 | Holzwickeder SC | - | Westfalia Herne | 1:1 | ||||
| 17. Round | 27/02/2022 | Westfalia Herne | - | ASC 09 Dortmund | 2:4 | ||||
| 18. Round | 06/03/2022 | SG Finnentrop/Bamenohl | - | Westfalia Herne | 4:0 | ||||
| 19. Round | 13/03/2022 | Westfalia Herne | - | 1. FC Kaan-Marienborn | 2:5 | ||||
| 21. Round | 27/03/2022 | Westfalia Herne | - | TuS Ennepetal | 1:5 | ||||
| 20. Round | 03/04/2022 | Viktoria Clarholz | - | Westfalia Herne | 2:0 |
Germany