| 1. Round | 28/08/2021 | SpVgg Vreden | - | FC Gütersloh | 0:2 | ||||
| 5. Round | 26/09/2021 | FC Gütersloh | - | Preußen Münster II | 4:1 |  |
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| 6. Round | 03/10/2021 | SC Paderborn 07 II | - | FC Gütersloh | 1:1 | ||||
| 7. Round | 10/10/2021 | FC Gütersloh | - | RSV Meinerzhagen | 3:0 | ||||
| 8. Round | 17/10/2021 | Westfalia Herne | - | FC Gütersloh | 1:2 | ||||
| 9. Round | 24/10/2021 | FC Gütersloh | - | Westfalia Rhynern | 2:1 | ||||
| 10. Round | 31/10/2021 | Holzwickeder SC | - | FC Gütersloh | 1:3 | ||||
| 11. Round | 07/11/2021 | FC Gütersloh | - | ASC 09 Dortmund | 1:0 | ||||
| 12. Round | 14/11/2021 | SG Finnentrop/Bamenohl | - | FC Gütersloh | 0:0 | ||||
| 13. Round | 20/11/2021 | FC Gütersloh | - | 1. FC Kaan-Marienborn | 1:2 | |
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| 18. Round | 06/03/2022 | FCE Rheine | - | FC Gütersloh | 0:2 |  |
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| 20. Round | 20/03/2022 | Hammer SpVg | - | FC Gütersloh | 0:0 | ||||
| 17. Round | 23/03/2022 | FC Gütersloh | - | SG Wattenscheid 09 | 0:0 | |
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| 19. Round | 07/04/2022 | FC Gütersloh | - | TSG Sprockhövel | 2:0 | |
Cameroon