| 1. Round | 16/07/2022 | FC St. Pauli | - | 1. FC Nürnberg | 3:2 |  |
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| 2. Round | 23/07/2022 | 1. FC Nürnberg | - | SpVgg Greuther Fürth | 2:0 | ||||
| 3. Round | 06/08/2022 | Jahn Regensburg | - | 1. FC Nürnberg | 0:0 | |
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| 4. Round | 12/08/2022 | 1. FC Nürnberg | - | 1. FC Heidenheim 1846 | 0:3 | ||||
| 5. Round | 20/08/2022 | SV Sandhausen | - | 1. FC Nürnberg | 1:2 | ||||
| 6. Round | 27/08/2022 | 1. FC Nürnberg | - | Hamburger SV | 0:2 | ||||
| 7. Round | 02/09/2022 | Eintracht Braunschweig | - | 1. FC Nürnberg | 4:2 | ||||
| 8. Round | 09/09/2022 | 1. FC Nürnberg | - | Arminia Bielefeld | 1:0 | |
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| 9. Round | 17/09/2022 | SV Darmstadt 98 | - | 1. FC Nürnberg | 2:0 | |
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| 10. Round | 02/10/2022 | Karlsruher SC | - | 1. FC Nürnberg | 3:0 | ||||
| 11. Round | 09/10/2022 | 1. FC Nürnberg | - | Holstein Kiel | 2:3 | ||||
| 12. Round | 15/10/2022 | Fortuna Düsseldorf | - | 1. FC Nürnberg | 0:1 | ||||
| 13. Round | 22/10/2022 | 1. FC Nürnberg | - | Hannover 96 | 0:0 | ||||
| 14. Round | 29/10/2022 | 1. FC Kaiserslautern | - | 1. FC Nürnberg | 0:0 | ||||
| 15. Round | 06/11/2022 | 1. FC Nürnberg | - | 1. FC Magdeburg | 1:2 | ||||
| 16. Round | 09/11/2022 | Hansa Rostock | - | 1. FC Nürnberg | 1:1 | ||||
| 17. Round | 13/11/2022 | 1. FC Nürnberg | - | SC Paderborn 07 | 2:1 |
Germany