3. Round | 12/09/2021 | SV Schermbeck | - | Holzwickeder SC | 2:3 | ||||
5. Round | 26/09/2021 | FCE Rheine | - | Holzwickeder SC | 3:0 | ||||
8. Round | 17/10/2021 | Holzwickeder SC | - | Sportfreunde Siegen | 0:2 | ||||
9. Round | 24/10/2021 | SpVgg Vreden | - | Holzwickeder SC | 1:0 | ||||
10. Round | 31/10/2021 | Holzwickeder SC | - | FC Gütersloh | 1:3 | ||||
11. Round | 07/11/2021 | TuS Haltern | - | Holzwickeder SC | 0:1 | ||||
12. Round | 14/11/2021 | Holzwickeder SC | - | TuS Erndtebrück | 0:6 | ||||
13. Round | 20/11/2021 | Preußen Münster II | - | Holzwickeder SC | 0:3 | ||||
14. Round | 25/11/2021 | Holzwickeder SC | - | SC Paderborn 07 II | 0:6 | ||||
15. Round | 05/12/2021 | RSV Meinerzhagen | - | Holzwickeder SC | 4:1 | ||||
16. Round | 12/12/2021 | Holzwickeder SC | - | Westfalia Herne | 1:1 |