| 2. Round | 30/08/1980 | BSG Sachsenring Zwickau | - | BFC Dynamo | 1:3 | ||||
| 3. Round | 06/09/1980 | BFC Dynamo | - | 1. FC Lokomotive Leipzig | 3:0 | ||||
| 4. Round | 13/09/1980 | FC Vorwärts Frankfurt/Oder | - | BFC Dynamo | 2:1 | ||||
| 5. Round | 20/09/1980 | BFC Dynamo | - | 1. FC Magdeburg | 1:1 | ||||
| 6. Round | 27/09/1980 | BSG Wismut Aue | - | BFC Dynamo | 0:5 | ||||
| 7. Round | 04/10/1980 | BFC Dynamo | - | Rot-Weiß Erfurt | 7:1 |  |
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| 9. Round | 25/10/1980 | BFC Dynamo | - | Hansa Rostock | 4:0 | ||||
| 11. Round | 15/11/1980 | BFC Dynamo | - | Dynamo Dresden | 2:1 | ||||
| 12. Round | 22/11/1980 | BFC Dynamo | - | BSG Stahl Riesa | 4:1 | |
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| 13. Round | 29/11/1980 | FC Carl Zeiss Jena | - | BFC Dynamo | 2:2 | ||||
| 14. Round | 21/02/1981 | HFC Chemie | - | BFC Dynamo | 2:1 | |
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| 15. Round | 28/02/1981 | BFC Dynamo | - | BSG Sachsenring Zwickau | 2:0 | ||||
| 16. Round | 07/03/1981 | 1. FC Lokomotive Leipzig | - | BFC Dynamo | 0:1 | ||||
| 17. Round | 14/03/1981 | BFC Dynamo | - | FC Vorwärts Frankfurt/Oder | 1:2 | ||||
| 18. Round | 21/03/1981 | 1. FC Magdeburg | - | BFC Dynamo | 2:4 | ||||
| 19. Round | 28/03/1981 | BFC Dynamo | - | BSG Wismut Aue | 5:1 | ||||
| 20. Round | 11/04/1981 | Rot-Weiß Erfurt | - | BFC Dynamo | 3:3 |
Germany