| 4. Round | 22/08/2021 | Greifswalder FC | - | 1. FC Lok Stendal | 2:0 | ||||
| 6. Round | 10/09/2021 | Greifswalder FC | - | MSV Pampow | 1:2 | ||||
| 8. Round | 26/09/2021 | Greifswalder FC | - | SFC Stern 1900 | 4:2 | ||||
| 9. Round | 03/10/2021 | Eintracht Mahlsdorf | - | Greifswalder FC | 0:1 |  |
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| 10. Round | 17/10/2021 | Greifswalder FC | - | RSV Eintracht 1949 | 2:2 | ||||
| 11. Round | 23/10/2021 | Ludwigsfelder FC | - | Greifswalder FC | 1:2 | ||||
| 14. Round | 20/11/2021 | Greifswalder FC | - | SC Staaken | 0:2 | ||||
| 15. Round | 06/02/2022 | FC Mecklenburg Schwerin | - | Greifswalder FC | 2:3 | ||||
| 19. Round | 06/03/2022 | Greifswalder FC | - | TSG Neustrelitz | 1:0 | |
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| 25. Round | 23/04/2022 | MSV Pampow | - | Greifswalder FC | 1:1 | ||||
| 26. Round | 01/05/2022 | Greifswalder FC | - | MSV 1919 Neuruppin | 3:0 |  |
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| 27. Round | 08/05/2022 | SFC Stern 1900 | - | Greifswalder FC | 1:3 | |
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| 29. Round | 26/05/2022 | RSV Eintracht 1949 | - | Greifswalder FC | 1:4 | ||||
| 30. Round | 29/05/2022 | Greifswalder FC | - | Ludwigsfelder FC | 1:0 | |
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| 31. Round | 04/06/2022 | Victoria Seelow | - | Greifswalder FC | 1:5 | |
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| 33. Round | 18/06/2022 | SC Staaken | - | Greifswalder FC | 6:0 |
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