| 17. Round | 20/01/2021 | MSV Duisburg | - | 1. FC Magdeburg | 1:2 | ||||
| 20. Round | 23/01/2021 | MSV Duisburg | - | Hansa Rostock | 1:2 | ||||
| 21. Round | 26/01/2021 | FSV Zwickau | - | MSV Duisburg | 3:1 | ||||
| 22. Round | 31/01/2021 | MSV Duisburg | - | VfB Lübeck | 3:1 |  |
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| 25. Round | 20/02/2021 | MSV Duisburg | - | SpVgg Unterhaching | 2:1 |  |
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| 26. Round | 28/02/2021 | KFC Uerdingen 05 | - | MSV Duisburg | 1:2 | |
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| 23. Round | 03/03/2021 | 1. FC Saarbrücken | - | MSV Duisburg | 4:1 | ||||
| 27. Round | 06/03/2021 | MSV Duisburg | - | TSV 1860 München | 1:0 | ||||
| 36. Round | 08/05/2021 | 1. FC Magdeburg | - | MSV Duisburg | 3:2 | ||||
| 37. Round | 15/05/2021 | MSV Duisburg | - | FC Ingolstadt 04 | 1:5 | ||||
| 38. Round | 22/05/2021 | SV Meppen | - | MSV Duisburg | 2:1 | |
Germany
Spain