| 6. Round | 15/10/2021 | Werder Bremen [Women] | - | SGS Essen [Women] | 1:0 | ||||
| 8. Round | 14/11/2021 | SGS Essen [Women] | - | SC Sand [Women] | 4:1 | ||||
| 9. Round | 21/11/2021 | VfL Wolfsburg [Women] | - | SGS Essen [Women] | 5:1 | ||||
| 10. Round | 05/12/2021 | SGS Essen [Women] | - | SC Freiburg [Women] | 0:1 | ||||
| 11. Round | 12/12/2021 | FC Carl Zeiss Jena [Women] | - | SGS Essen [Women] | 0:4 | ||||
| 12. Round | 17/12/2021 | 1. FC Köln [Women] | - | SGS Essen [Women] | 2:1 | ||||
| 13. Round | 05/02/2022 | SGS Essen [Women] | - | Bayer Leverkusen [Women] | 1:1 | ||||
| 14. Round | 13/02/2022 | 1899 Hoffenheim [Women] | - | SGS Essen [Women] | 2:1 | ||||
| 15. Round | 06/03/2022 | SGS Essen [Women] | - | Turbine Potsdam [Women] | 0:5 | ||||
| 18. Round | 27/03/2022 | Bayern München [Women] | - | SGS Essen [Women] | 4:0 | ||||
| 19. Round | 03/04/2022 | SC Sand [Women] | - | SGS Essen [Women] | 1:1 | ||||
| 20. Round | 04/05/2022 | SGS Essen [Women] | - | VfL Wolfsburg [Women] | 1:5 | ||||
| 21. Round | 08/05/2022 | SC Freiburg [Women] | - | SGS Essen [Women] | 3:0 | ||||
| 22. Round | 15/05/2022 | SGS Essen [Women] | - | FC Carl Zeiss Jena [Women] | 3:0 |  |
Germany