| 1. Round | 15/08/2021 | FC Carl Zeiss Jena [Youth] | - | VfL Osnabrück [Youth] | 0:0 | ||||
| 3. Round | 12/09/2021 | VfL Osnabrück [Youth] | - | Holstein Kiel [Youth] | 0:2 | ||||
| 4. Round | 19/09/2021 | RB Leipzig [Youth] | - | VfL Osnabrück [Youth] | 4:0 | ||||
| 5. Round | 26/09/2021 | VfL Osnabrück [Youth] | - | Chemnitzer FC [Youth] | 1:0 | ||||
| 6. Round | 03/10/2021 | Eimsbütteler TV [Youth] | - | VfL Osnabrück [Youth] | 2:1 | ||||
| 8. Round | 24/10/2021 | FC Viktoria 1889 Berlin [Youth] | - | VfL Osnabrück [Youth] | 2:2 | ||||
| 9. Round | 31/10/2021 | VfL Osnabrück [Youth] | - | Hallescher FC [Youth] | 0:1 | ||||
| 12. Round | 05/12/2021 | Hertha BSC [Youth] | - | VfL Osnabrück [Youth] | 4:0 |
Germany