| 15. Round | 21/10/2017 | TuS Koblenz | - | 1899 Hoffenheim II | 0:1 | ||||
| 20. Round | 19/11/2017 | Kickers Offenbach | - | 1899 Hoffenheim II | 1:1 | ||||
| 21. Round | 25/11/2017 | 1899 Hoffenheim II | - | TSV Schott Mainz | 2:0 | ||||
| 24. Round | 11/02/2018 | 1899 Hoffenheim II | - | SSV Ulm 1846 | 1:1 | ||||
| 26. Round | 25/02/2018 | 1899 Hoffenheim II | - | SV 07 Elversberg | 1:1 |  |
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| 25. Round | 07/03/2018 | Hessen Kassel | - | 1899 Hoffenheim II | 2:1 | |
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| 28. Round | 10/03/2018 | 1899 Hoffenheim II | - | SC Freiburg II | 0:1 | ||||
| 29. Round | 17/03/2018 | Stuttgarter Kickers | - | 1899 Hoffenheim II | 2:2 | ||||
| 32. Round | 01/04/2018 | 1899 Hoffenheim II | - | Wormatia Worms | 2:2 | ||||
| 34. Round | 15/04/2018 | 1899 Hoffenheim II | - | TuS Koblenz | 2:2 | |
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| 35. Round | 21/04/2018 | Eintracht Stadtallendorf | - | 1899 Hoffenheim II | 3:1 | |
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| 36. Round | 28/04/2018 | 1899 Hoffenheim II | - | Waldhof Mannheim | 2:2 |
Germany